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The phosphorylated HER3 gives docking web-sites for p85 subunit of PI3K. The thoroughly activated PI3K elaborate is produced by binding of p110 subunit of PI3K to p85 which is ready to produce PIP3 through phosphorylating the PIP2. AKT binds to PIP3 and is particularly phosphorylated by PDK1 and mTORC2. Phosphorylation of AKT at both of those threo